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Dr. Yi-Po Anthony Wu


Yi-Po Anthony Wu, MD, M.P.H.
Medical Director and founder of PCMC

  • Western medical training at National Taiwan University, Worcester City Hospital, University of Massachusetts Medical Center
  • Masters degree in Public Health, University of Hawaii
  • Diplomate, American Board of Internal Medicine
  • Acupuncture training in Taiwan and at New York University
  • Director of Pacific Pain Clinic 1988-93
  • Director of Pacific Complementary Medicine Center since 1999
 
An Interview With Dr. Anthony Wu About Hormone Replacement Therapy (HRT)
By Beth Luna
How should a woman deal with synthetic hormone replacement therapy?

Take Mary's case for instance, she has been taking Premarin for more than 20 years following her hysterectomy. After the news report in June of this year on the side effects of synthetic hormones, she wanted to stop.

If she did, what could she do to prevent osteoporosis, hot flashes, night sweats and all that goes with the menopause syndrome? Or should she continue and risk the increased probability of breast cancer? I am here to share with you vital information on treatment options and provide some insight that may help you reach a personal decision.

Is there any validation to this hormone scare?

First, some background material, as given in Internal Medicine News, August, 2002. The debate of hormone replacement therapy has been carried on for about 40 years since its inception. The Women's Health Initiative study with its results, published this June, is most important, because it is the first randomized, double-blind primary preventive trial (i.e. most scientifically accurate).

The study was originally planned for eight years, but was terminated three years early because data indicated high risks for participants, i.e. human subjects. So therefore, there is validity to the scare.

Are there any hormone pills that are safe for a person to take?

More and more people are using "natural" bio-identical hormones because of their distrust for synthetic drugs. Though there has not been any long-term study on bio-identical hormones, research at the laboratory indicates that they have fewer side effects. Because of the complexity in hormone therapy, these bio-identical hormones are best prescribed by physicians and monitored accordingly. It is necessary to find a pharmacy that can prepare these prescriptions.

Some bio-identical hormones such as progestin and progesterone cream can be purchased at health food stores without prescription. If symptoms persist after three months of use, consult a physician or health provider who is knowledgeable in holistic hormone treatment.

Will you comment on the birth control pill?

For the younger woman who is taking synthetic hormones for birth control, I would recommend that she slowly changes to natural hormones and then to herbs. The timing depends on her endocrinal hormone cycle, her life style, stress level and diet.

A lot of women take Provera, the birth control pill, which is a synthetic hormone. The body has no way of handling synthetics, so this remains in the system and accumulates. Provera will stop ovulation, thus providing birth control. When it is discontinued, the menstrual cycle may become irregular, or it may remain regular but with no ovulation, thus extending infertility whether you want it or not. The body has no enzyme with which to digest this synthetic Provera. It is true that women have a right to control their bodies, but they also need to be aware of these facts.

After a hysterectomy, or in old age, does the body stop producing hormones?

When there is a hysterectomy, in most cases the ovaries are also removed, but this does not mean that the power to create hormones ceases. The adrenals now take over, and handles most of the functions that belonged to the ovaries, but on a smaller scale. Progesterone is one of the hormones produced by the adrenals.

Older people can get by on a minimal amount of hormones. Often, for them, herbs can be the answer. Commonly used are: chaste berry, horsetail, black cohosh, dang gui (angelica sinensis), ginseng and licorice. Some Chinese herb formulas, combining several herbs together with synergetic effects have been found to be very useful.

What can a woman do who is taking hormones and wants to change?

If she is already on synthetic hormones and wishes to convert to bio-identical hormones or herbs, she should allow a couple months for the transition. During this period, reduce synthetic dosage gradually (to maybe a couple times a week), while adding the natural replacements. It is important to make the change slowly.

Our bodies are miracles. We can tolerate a lot of chemicals and still survive. For a better life than survival we need to shift back to a more natural life style; eat more organic foods and exercise.

What else can a woman do for herself?

The alternative to taking synthetic hormones is a good diet, good rest and exercise. Also, as mentioned above, you can take natural hormones. It has been proven that natural progestin works a lot better than the synthetic in preventing osteoporosis.

Do all women suffer through menopause?

Statistics show that 50% of women in the United States experience the menopausal syndrome. In Japan, only 6% suffer with the 'change of life.' The Japanese do not even acknowledge the menopause as a disease. Diet in Japan, which includes soy products, less meat, more vegetables and food from the ocean, is credited with the easy passage.

Are there any outside factors that aggravate, over which a woman has no control?

Many of our problems can be attributed to pesticides. They go into the ground, become part of our plants, and get into our water supply. Then there are other powerful pharmaceutical companies which promote the use synthetic hormones.

Thank you for sharing this valuable information.

Locally, Dr. Wu will work with you, directly, or with your primary care physician or gynecologist to develop a treatment program most beneficial to your needs.

PCMC also provides a wide spectrum of medical services, including acupuncture, exercise classes and an herb store to help you lead a healthy life style. See also articles in the Fall 2002 newsletter by Yoshiko Kage, Dorel Rotar and Michael Nian-Peng Shi, members of our staff, for more information.




NATURAL HORMONES FROM PLANTS

Certain plant foods such as soybean and flaxseed contain estrogen-likesubstances that regulate or stabilize hormones. The isoflavones in soy products are referred to as phytoestrogen because of their plant origin.


Isoflavones act as adaptogens in that "If a woman has an excessive amount of estrogen, these substances help to block the estrogen from entering estrogen receptor sites. If there is not enough estrogen, they fill the gap." (Kamen, p.73) The adaptogenic, phytoestrogenic activities help reduce hot flashes and other menopausal symptoms.

Other sources of phytoestrogen include chaste berry, black cohosh, dong quai, licorice, and panax ginseng. Whereas dong quai and licorice appear to modulate estrogen action, panax ginseng shows estrogenic effects on the vaginal lining, helping to relieve dryness and pain.


Phytochemicals in chaste berry tend to effect a relative increase in progesterone and a relative decrease in estrogen, thus making it particularly useful for PMS and heavy menstrual periods.
Phytochemicals in black cohosh, on the other hand, shift the estrogen/progesterone ratio

towards estrogens, an effect opposite in some ways to that of chaste berry and is useful in relieving menstrual cramps and against depression at the time of menopause. (Wright & Morgenthaler, p.112)


There are hundreds of other plant foods that contain small quantities of phytoestrogen; a few even with identical-to-human hormones. These foods have not undergone extensive research simply because plants are not patentable.





Recommended Reading by Dr. Wu


Hsu, Dr. Hong-yen & Douglas H. Easer. 1982. For Women Only: Chinese Herbal Formulas. New Canaan, Connecticut: Keats Publishing, Inc.

Kamen, Betty, Ph.D. 1996. Hormone Replacement Therapy: Yes or No? Novato, CA: Nutrition Encounter.

Lee, John R., M.D. and Virginia Hopkins. 1996. What Your Doctor May Not Tell You about MENOPAUSE. New York, NY: Warner Books. .

Lee, John R., M.D., Jesse Hanley, M.D., and Virginia Hopkins. 1999. What Your Doctor May Not Tell You about PREMENOPAUSE. New York, NY: Warner Books.

Sears, Barry, Ph.D. 2000. The Soy Zone. New York, NY: HarperCollins Publishers, Inc.

Wright, Jonathon V., M.D. & John Morgenthaler. Natural Hormone Replacement. Petaluma, CA: Smart Publications.




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